Table 4 cis-eQTLs and their same-chromosome target genes identified in non-involved lung tissue from 232 lung adenocarcinoma patients (analysis limited to 10 confirmed SNPs. eQTLs clustered into two main loci.

From: Genetic susceptibility variants for lung cancer: replication study and assessment as expression quantitative trait loci

eQTL

SNP

Chr.

Position (bp) a

Target gene

Nominal P

FDR

Beta b

1

rs2568494

15

78,448,622

IREB2

1.35 × 10−6

0.00018

−0.21

2

rs16969968

15

78,590,583

IREB2

5.70 × 10−6

0.00035

−0.20

3

rs11634351

15

78,652,376

IREB2

0.00158

0.035

−0.15

4

rs6495309

15

78,622,903

IREB2

0.000218

0.0098

0.21

5

rs6495309

15

78,622,903

PSMA4

0.00100

0.027

0.092

6

rs735482

19

45,408,744

ERCC1

0.000711

0.029

−0.12

  1. aMap position based on genome assembly GRCh38.p5.
  2. bBeta values are from the additive linear regression model (in MatrixEQTL R package), where genotype (expressed as the minor allele count) is assumed to have an additive effect on gene expression. Patients’ sex and age at surgery were used as covariates. A positive value indicates that the expression of the target gene increases with an increase in minor allele count.
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