Table 1 Correlations between AKR1B10 expression and clinicopathologic characteristics of patients with HBV-related hepatocellular carcinoma.
Characteristics | n | AKR1B10 expression | χ 2 | P value | |
|---|---|---|---|---|---|
Low n (%) | High n (%) | ||||
Gender | |||||
 Male | 96 | 37 (38.5) | 59 (61.5) | 0.096 | 0.757 |
 Female | 14 | 6 (42.9) | 8 (57.1) |  |  |
Age (years) | |||||
 <60 | 86 | 33 (38.4) | 53 (61.6) | 0.086 | 0.770 |
 ≥60 | 24 | 10 (41.7) | 14 (58.3) |  |  |
AFP (ng/ml) | |||||
 <200 | 44 | 12 (27.3) | 32 (72.7) | 4.302 | 0.038 |
 ≥200 | 66 | 31 (47.0) | 35 (53.0) |  |  |
HBV-DNA (copies/ml) | |||||
 <1000 | 27 | 15 (55.6) | 12 (44.4) | 4.074 | 0.044 |
 ≥1000 | 83 | 28 (33.7) | 55 (66.3) |  |  |
Cirrhosis | |||||
 Yes | 92 | 34 (37.0) | 58 (63.0) | 1.076 | 0.300 |
 No | 18 | 9 (50.0) | 9 (50.0) |  |  |
Tumor size (cm) | |||||
 ≤5 | 37 | 11 (29.7) | 26 (70.3) | 2.052 | 0.152 |
 >5 | 73 | 32 (43.8) | 41 (56.2) |  |  |
Tumor number | |||||
 1 | 83 | 31 (37.3) | 52 (62.7) | 0.431 | 0.512 |
 ≥2 | 27 | 12 (44.4) | 15 (55.6) |  |  |
Macrovascular invasion | |||||
 Yes | 19 | 7 (36.8) | 12 (63.2) | 0.049 | 0.825 |
 No | 91 | 36 (39.6) | 55 (60.4) |  |  |
BCLC stage | |||||
 A | 67 | 27 (40.3) | 40 (59.7) | 0.105 | 0.746 |
 B or C | 43 | 16 (37.2) | 27 (62.8) |  |  |
Differentiation degree | |||||
 Well or moderately | 68 | 25 (46.8) | 43 (63.2) | 0.405 | 0.525 |
 Poorly | 42 | 18 (42.9) | 24 (57.1) |  |  |
