Figure 5: Analysis of spine density and morphology of LEC neurons in 2 month old mice. | Scientific Reports

Figure 5: Analysis of spine density and morphology of LEC neurons in 2 month old mice.

From: Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer’s disease mouse model

Figure 5

(A) Representative Golgi-stained EC slices and layer II neurons (scale bar = 250 μm). Magnification (40×, scale bar = 100 μm) shows a pyramidal (bottom) and a multiform (upper) neuron in the lateral EC. (B) Plots reporting the average spine density calculated for each genotype. (C) Representative dendritic segments of Golgi-stained EC layer II neurons are reported for each genotype (100× magnification, scale bar = 5 μm). Spines were classified as thin or large based on their morphology (shape and dimension); examples of thin (white arrows) and large (empty arrows) spines are reported for mhAPP mice. In (D) The plots represent the average density of thin and large spines calculated for ach genotype. Data are presented as mean ± SEM (*p < 0.05).

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