Figure 6: The increase of p38 MAPK/JNK phosphorylation in the EC of mhAPP mice is prevented by microglial RAGE inhibition. | Scientific Reports

Figure 6: The increase of p38 MAPK/JNK phosphorylation in the EC of mhAPP mice is prevented by microglial RAGE inhibition.

From: Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer’s disease mouse model

Figure 6

In (A) the plot represents averaged phospho-p38 MAPK levels measured using ELISA and expressed as unit/total content of p38 MAPK protein. Tissue levels of phospho-p38 MAPK were significantly higher in the EC of mhAPP mice with respect to control WT slices (*°p < 0.05) both in 2 and in 6 month old animals. Selective deficiency of RAGE signalling in microglia (DNMSR) did not modify basal level of phospho-p38 MAPK and was capable of preventing the increase of phospho-p38 MAPK in mhAPPxDNMSR mice at either 2 or 6 months of age. In (B) the plot represents averaged phospho-JNK levels measured using ELISA and expressed as unit/total content of JNK protein. Phospho-JNK levels were increased in the EC of 6 month old mhAPP mice (*p < 0.05 vs. WT) but not in that of 2 month old mhAPP mice. Deficiency of RAGE signalling in microglia (DNMSR) did not modify basal level of phospho-JNK but was able to prevent the increase of phospho-JNK in mhAPPxDNMSR mice.

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