Table 2 Mutation occurrence in HBV infected treatment-naïve patients.

From: Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

 

NCBI

UDPS

Prevalence

Prevalence

Intra-host frequency

Core T33N

3/3953 (0.075%)

0/50 (0%)

—

Core T33S

2/3953 (0.05%)

0/50 (0%)

—

Core P25S

0/3953 (0%)

1/50 (2%)

2.47%

Core V124F

0/3953 (0%)

4/50 (8%)

1.12%, 1.46%, 2.06%, 2.08%

  1. Prevalence of the core protein variants at selected sites from NCBI database and from UDPS results is listed here. 3953 sequences from NCBI were analyzed. UDPS was performed on HBV samples from 50 chronically HBV infected treatment-naïve Chinese patients. Intra-host frequency in UDPS denotes the abundance of the mutations within the sample viral population. The detection limit for UDPS is 0.05%.
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