Table 2 Bivariate and multivariate Cox regression analysis on immunologic treatment failure among patients initiating ART from 2005 to 2013, Jiangsu province, China (N = 5,083).
From: Immunologic treatment failure among HIV-infected adult patients in Jiangsu province, China
Variables | Bivariate | Multivariate | ||
|---|---|---|---|---|
P value | HR (95%CI) | P value | HR (95%CI) | |
Guideline on ART eligibility | ||||
CD4 ≤ 200 cells/uL in period 2005–2009 | 1 | 1 | ||
CD4 ≤ 350 cells/uL in period 2010–2013 | 0.008 | 1.23 (1.06, 1.44) | 0.033 | 1.19 (1.01, 1.40) |
Age(ys) | ||||
≤20 | 1 | |||
21~40 | 0.986 | 0.10 (0.66, 1.51) | ||
41~60 | 0.620 | 1.11 (0.73, 1.69) | ||
>60 | 0.170 | 1.37 (0.87, 2.14) | ||
Gender | ||||
Male | 1 | |||
Female | 0.017 | 0.85 (0.75, 0.97) | ||
Jiangsu province residency | ||||
Yes | 1 | |||
No | 0.008 | 0.83 (0.73, 0.95) | ||
Marital status | ||||
Married or cohabiting | 1 | |||
Single | 0.969 | 1.00 (0.89, 1.13) | ||
Divorced or widowed | 0.203 | 1.09 (0.95, 1.25) | ||
Facility providing ART | ||||
Hospital | 1 | 1 | ||
CDC | 0.004 | 1.16 (1.05, 1.29) | 0.009 | 1.69 (1.14, 2.50) |
Jail hospital | 0.001 | 1.92 (1.31, 2.83) | 0.001 | 1.20 (1.08 1.34) |
Transmission route | ||||
Blood transfusion | 1 | |||
Mother to child | 0.702 | 0.83 (0.31, 2.19) | ||
Injecting drug uses | 0.841 | 0.92 (0.39, 2.15) | ||
Male to male sex | 0.407 | 0.79 (0.45, 1.39) | ||
Heterosexual sex | 0.549 | 0.84 (0.48, 1.48) | ||
Unsure | 0.992 | 1.01 (0.29, 3.54) | ||
Most recent CD4 count prior to ART initiation | ||||
≤100 | 1 | 1 | ||
101~200 | <0.001 | 0.71 (0.61, 0.82) | <0.001 | 0.72 (0.62, 0.83) |
201~350 | 0.255 | 0.93 (0.83, 1.05) | 0.804 | 0.98 (0.86, 1.12) |
>350 | <0.001 | 2.29 (1.90, 2.77) | <0.001 | 2.37 (1.94, 2.89) |
