Figure 1

Testicular weight (a) and induction rate (b) of EAEO in animals used in the study. Paired testicular weight of untreated, adjuvant control and EAEO mice 30, 50 and 80 days after the first immunisation (a). Data are expressed as mean ± SEM (n = 4–7 animals per group, numbers of animals per group are shown in the respective columns); ****P < 0.0001, all other comparisons are not statistically significant. Representative image shows macroscopic difference in testicular size from control and EAEO mice 50 days after the first immunisation (c).