Figure 2: Effect of pemafibrate and fenofibrate on hepatic inflammation. | Scientific Reports

Figure 2: Effect of pemafibrate and fenofibrate on hepatic inflammation.

From: Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis

Figure 2

(A) Liver sections from BD, CTRL, PEMA-L, PEMA-H, and FENO mice. F4/80 staining. Magnification, 200x. Scale bars: 100 μm. (B) The number of macrophages was counted in the livers of BD, CTRL, PEMA-L, PEMA-H, and FENO mice (n = 5). (C) Expression of tumour necrosis factor α (TNFα) mRNA in BD, CTRL, PEMA-L, PEMA-H, and FENO mice (n = 5–10). Results are the mean ± SE. Significance was determined using Student’s t-test (†p < 0.05 versus CTRL mice) or Dunnett’s test (*p < 0.05 versus CTRL mice).

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