Figure 3: Effect of pemafibrate and fenofibrate on hepatic fibrosis. | Scientific Reports

Figure 3: Effect of pemafibrate and fenofibrate on hepatic fibrosis.

From: Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis

Figure 3

(A) Liver sections from BD, CTRL, PEMA-L, PEMA-H, and FENO mice. Sirius red staining. Magnification, 100x. Scale bars: 200 μm. (B) Areas of Sirius red staining in the livers of BD, CTRL, PEMA-L, PEMA-H, and FENO mice were measured (n = 5). (C) Expression of collagen 1α1 mRNA in BD, CTRL, PEMA-L, PEMA-H, and FENO mice (n = 5–10). Results are the mean ± SE. Significance was determined using Student’s t-test (†p < 0.05 versus CTRL mice) or Dunnett’s test (*p < 0.05 versus CTRL mice).

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