Table 2 The imipenem and ciprofloxacin secondary resistomes in Klebsiella pneumoniae ST258.

From: The secondary resistome of multidrug-resistant Klebsiella pneumoniae

Gene/operon

Function

Imipenem

Ciprofloxacin

LogFC

LogCPM

q value

LogFC

LogCPM

q value

nhaA

pH dependent Na+/H+ antiporter

−2.22

4.51

2.38E-13

   

ydiE

hypothetical protein

   

−2.67

2.20

0.013926

  1. Genes/operons for which insertion sequence abundance was significantly (≥4 fold) depleted when the mutant library was cultured in the presence of 2 μg/ml of imipenem or ciprofloxacin were identified by Transposon Directed Insertion-site Sequencing (TraDIS) analysis. Differences in insertion sequence abundance compared to the unexposed (control) culture of the library are expressed by log2 fold change (logFC). Number of insertion site sequence reads for the mentioned gene are presented by log2 counts per million (LogCPM). Quality of data is indicated by (q) value, where q ≤ 0.01 is significant.
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