Figure 2: The co-expression/correlation network potentially targeted by let-7e.
From: Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk
(a) The co-expression/correlation network of the aforementioned 487 transcripts was constructed as described in the Methods section. The lines between nodes represented significant co-expression/correlations (|r| > 0.99 and p < 0.05). (b) The shortlisting network comprising core nodes extracted from the whole network using ModuLand. The color of a core node represented a cluster of nodes in the entire network. (c) The core subnetwork was extracted from the whole network using MCODE, comprising transcripts significantly co-expressed with IκBβ (NFKBIB). (d) The expression data of the nodes constituting this network presented in (c) in different groups were hierarchically clustered. IκBβ and lnc-MKI67IP-3, the most connected nodes, were highlighted and their expression changes were most notable in these nodes.
