Table 2 Univariate and multivariate analyses of factors associated with pre-therapy HCV RNA and PAI-1 levels as well as SVR in all enrolled chronic hepatitis C patients.
Variants | HCV RNA (Log10 IU/ml) | PAI-1 (ng/ml) | SVR | |||
|---|---|---|---|---|---|---|
Univariate analysis: 95% CI of estimated β (p-values) | Multivariate analysis: 95% CI of estimated β [estimated β] (p-values) | Univariate analysis: 95% CI of estimated β (p-values) | Multivariate analysis: 95% CI of estimated β [estimated β] (p-values) | Univariate analysis: 95% CI of OR [OR] (p-values) | Multivariate analysis: 95% CI of OR [OR] (p-values) | |
Sex (Male) | −0.839~2.037 (0.413) | −0.038~1.019 (0.069) | 0.707~1.877 [1.151] (0.571) | |||
Age | −0.068~0.047 (0.721) | −0.079~−0.034 (<0.001*) | −0.062~−0.002 [−0.032] (0.037*) | 0.961~1.004 [0.982] (0.11) | ||
BMI | −0.233~0.167 (0.746) | 0.12~0.225 (<0.001*) | 0.075~0.265 [0.17] (<0.001*) | 0.877~0.977 [0.935] (0.042*) | 0.82~0.992 [0.902](0.033*) | |
HCV genotype | −0.279~−0.14 (<0.001*) | −0.311~−0.098 [−0.204] (<0.001*) | −0.286~0.223 (0.807) | 1.361~3.604 [2.214] (0.001*) | 2.356~16.156 [0.617] (<0.001*) | |
HCV RNA (Log10 IU/ml) | NA | NA | −0.004~0.49 (0.053) | 0.385~0.708 [0.522] (<0.001*) | 0.464~1.307 [0.694] (0.075) | |
ALT (U/L) | −0.011~0.008 (0.777) | −001~0.005 (0.158) | 0.999~1.007 [1.003] (0.11) | |||
APRI | −0.481~0.318 (0.689) | −0.364~−0.008 (0.002) | −0.152~0.337 [0.093] (0.457) | 0.802~1.060 [0.922] (0.252) | ||
hsCRP (mg/dL) | −0.019~0.028 (0.702) | −0.068~0.19 (0.352) | 0.92~1.118 [1.014] (0.774) | |||
WBC count (103/μL) | 0.021~0.11 (0.004*) | 0.021~0.135 [0.078] (0.008*) | 0.223~0.492 (<0.001*) | −0.094~0.298 [0.102] (0.307) | 0.905~1.209 [1.046] (0.542) | |
Platelets count (103/μL) | 0.000~0.002 (0.212) | 0.014~0.022 (<0.001*) | 0.009~0.025 [0.017] (<0.001*) | 1.003~1.012 [1.008] (0.001*) | 0.997~1.013 [1.005] (0.216) | |
TC (mg/dL) | −0.016~0.031 (0.531) | −0.008~0.008 (0.96) | 0.992~1.007 [0.999] (0.843) | |||
TGs (mg/dL) | 0.006~0.032 (0.005*) | −0.003~0.002 [−0.001] (0.607) | 0.007~0.17 (<0.001*) | 0.002~0.016 [0.009] (0.012*) | 0.99~0.999 [0.995] (0.019*) | 0.991~1.004 [0.917] (0.46) |
HOMA-IR | 0.086~0.348 (0.001*) | −0.008~0.035 [0.013] (0.231) | −0.038~0.049 (0.813) | 0.909~1.004 [0.955] (0.073) | ||
Hepatic steatosis | −3.06~0.386 (0.128) | 0.401~1.529 (0.001*) | −0.284~1.227 [0.472] (0.22) | 0.725~2.048 [1.219] (0.455) | ||
Liver cirrhosis | −0.342~0.069 (0.192) | −1.728~−0.41 (0.001*) | −0.569~1.269 [0.33] (0.47) | 0.227~0.673 [0.391] (0.001*) | 0.109~0.684 [0.273] (0.006*) | |
PAI-1 (ng/ml) | −0.297~0.186 (0.65) | NA | NA | 0.919~1.117 [1.013] (0.794) | ||
BNP (Log10 pg/mL) | −0.383~0.264 (0.717) | −0.571~1.052 (0.377) | 0.128 ~0.828 [0.326] (0.018*) | 0.045~0.818 [0.192] (0.026*) | ||
Homocysteine (μmol/L) | −0.044~0.007 (0.155) | −0.12 ~0.017 (0.14) | 0.945~1.080 [1.011] (0.758) | −0.044~0.007 (0.155) | ||
eGFR | −0.001~0.004 (0.235) | −0.005~0.011 (0.427) | 0.992~1.008 [1.000] (0.948) | |||
PAI-1- SNP | ||||||
rs2227631 | −0.176~0.15 (0.887) | −0.507~0.435 (0.913) | 0.431~1.118 [0.694] (0.133) | |||
rs1799889 (4 G/4 G) | −0.28~0.025 (0.1) | 0.012~0.888 (0.044*) | 0.046~0.896 [0.471] (0.03*) | 0.746~1.636 [1.104] (0.62) | ||
PAI-1-associated SNPs | ||||||
rs6976053 | −0.146~0.129 (0.903) | −0.46~0.388 (0.868) | 0.671~1.464 [0.991] (0.964) | |||
rs6486112 | −0.18~0.133 (0.769) | −0.713~0.263 (0.365) | 0.597~1.557 [0.964] (0.88) | |||
rs11128603 | −0.271~0.501 (0.563) | −1.168~1.157 (0.922) | 0.439~0.882 [1.967] (0.377) | |||
IFNL3 SNP rs12979860 (CC) | −01.371 ~4.7 (0.278) | −1.34~0.347 (0.248) | 1.289~3.921 [2.248] (0.004*) | 1.324~4.707 [2.496] (0.005*) | ||
