Figure 2: Bone marrow transplantation reveals a critical role for Panx1 in hematopoietic cells following nerve injury. | Scientific Reports

Figure 2: Bone marrow transplantation reveals a critical role for Panx1 in hematopoietic cells following nerve injury.

From: Hematopoietic pannexin 1 function is critical for neuropathic pain

Figure 2

(A,B) Study design55. (C,D) Mechanical hypersensitivity following SNI was restored in Panx1−/− mice reconstituted with wild-type marrow and diminished in Panx1+/+ mice reconstituted with Panx1−/− marrow. (E,F) SNI-induced mechanical hypersensitivity in mice reconstituted with cells of the same genotype. (G) Flow cytometry showing GFP fluorescence in bone marrow from C57BL/6 mice or UBI-GFP mice. (H) GFP fluorescence after bone marrow transplantation of cells from UBI-GFP or mice of the indicated Panx1 genotypes demonstrating successful irradiation and replacement. Statistical analysis of behavioral data as in Fig. 1.

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