Figure 4: KPT-8752 and KPT-9274 cause an increase in cellular apoptosis in breast cancer cells. | Scientific Reports

Figure 4: KPT-8752 and KPT-9274 cause an increase in cellular apoptosis in breast cancer cells.

From: A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth

Figure 4

SUM159 (triple negative) (A), MCF7 (ER+/PR+) (B), SkBr-3 (HER2+) (C) and WT iMMEC (control) cells (D) were treated with either (i) DMSO (15 μM), (ii) KPT-8752 (3 μM), or (iii) KPT-9274 (1 μM) for 72 hours followed by staining for Annexin V/Propidium Iodide (PI). For all cell types, L3 represents the proportion of cells that have low intensity of Annexin V and PI staining and hence have low apoptotic activity, L4 represents the proportion of cells that stain more intensely for Annexin V indicating the early stages of apoptosis, and L2 represents cells that have high levels of Annexin V and PI representing highly apoptotic cells.

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