Table 1 Summary of In-vivo data from Fig. 5.
Cell line | No. of tumor (n) | Dosing Regimen | Average Tumor Volume (mm3) (Endpoint) | Average Tumor Weight (mg) | |||
|---|---|---|---|---|---|---|---|
KPT-9274 | Placebo | KPT-9274 | Placebo | KPT-9274 | Placebo | ||
MDA-MB-231 | 16 | 20 | 150 mg/kg PO bidx4 | 128 + 21.7 | 515.1 + 81.6 | 64.2 + 9.6 | 300.2 + 55.8 |
MDA-MB-468 | 8 | 7 | 100 mg/kg PO bidx4 | 398.7 + 41 | 1053.8 + 76 | — | — |
SUM159 | 10 | 10 | 150 mg/kg PO bidx4 | 187 + 33.7 | 524.2 + 90.2 | 160.8 + 19 | 463.1 + 81.1 |
