Table 1 Genes with negative correlation between gene expression and methylation.

From: Identification of Methylation-Driven, Differentially Expressed STXBP6 as a Novel Biomarker in Lung Adenocarcinoma

Gene	Exp. Probe ID ^a	Methylation Probe ID ^b	CpG Target No.	Corr. ^c	Exp. Diff. (log₂) ^d	P-value for Exp. ^e	Beta Diff. (T vs N)	Tumor Beta value	Normal Beta value	Methyla-tion Diff. (M value) ^f	P-value for Methyla-tion ^g
AQP1	209047_at	4600	cg04551925	−0.63	−1.83	2.10E-08	0.16	0.73	0.57	1.03	1.52E-07
HABP2	206010_at	26621	cg26656452	−0.61	1.89	3.91E-07	−0.23	0.58	0.81	−1.76	1.33E-08
SPDEF	220192_x_at	17272	cg17240454	−0.59	0.81	1.88E-08	−0.19	0.55	0.74	−1.12	2.64E-08
EHF	232361_s_at	18421	cg18414381	−0.59	1.29	7.14E-07	−0.17	0.28	0.45	−0.93	1.52E-09
HMGN1	200944_s_at	18826	cg18829411	−0.57	0.58	1.60E-08	−0.16	0.31	0.47	−1.01	4.89E-09
SLC22A18	204981_at	16913	cg16873863	−0.57	1.07	1.79E-07	−0.23	0.40	0.63	−1.35	1.90E-09
ARHGEF19	226857_at	18670	cg18669381	−0.56	1.20	7.74E-09	−0.11	0.29	0.40	−0.69	2.32E-07
IL11RA	204773_at	3676	cg03662459	−0.56	−0.74	8.98E-08	0.09	0.68	0.59	0.59	2.00E-07
GSTM5	205752_s_at	5031	cg04987894	−0.55	−0.69	1.57E-07	0.21	0.52	0.31	1.04	3.51E-11
NIPSNAP1	201709_s_at	13745	cg13797031	−0.55	0.70	2.14E-08	−0.26	0.49	0.75	−1.79	3.35E-09
MESP1	224476_s_at	1105	cg01091565	−0.54	1.24	9.77E-07	−0.18	0.62	0.80	−1.28	1.72E-08
EHF	232361_s_at	13011	cg13084525	−0.54	1.29	7.14E-07	−0.08	0.20	0.28	−0.71	1.36E-08
CP	228143_at	17465	cg17439694	−0.53	2.57	2.65E-07	−0.13	0.54	0.67	−0.91	2.26E-07
SPDEF	220192_x_at	7679	cg07705908	−0.53	0.81	1.88E-08	−0.21	0.36	0.57	−1.13	1.90E-08
HDHD3	221256_s_at	23967	cg24012708	−0.53	0.59	3.26E-07	−0.15	0.44	0.59	−0.95	1.53E-07
DCC	238914_at	4292	cg04272086	−0.52	−0.98	2.90E-09	0.13	0.20	0.07	1.48	1.21E-10
STXBP6	220994_s_at	6937	cg06948294	−0.52	−2.07	8.79E-12	0.11	0.15	0.04	1.62	1.68E-08
COX7A1	204570_at	24277	cg24335895	−0.52	−1.27	7.66E-10	0.22	0.52	0.30	1.44	2.71E-11
SPDEF	213441_x_at	17272	cg17240454	−0.52	0.53	5.98E-08	−0.19	0.55	0.74	−1.12	2.64E-08
RHOJ	243481_at	18774	cg18771300	−0.52	−1.25	1.19E-10	0.21	0.52	0.31	1.05	1.20E-07
CP	1558034_s_at	17465	cg17439694	−0.51	2.52	3.28E-09	−0.13	0.54	0.67	−0.91	2.26E-07
PECAM1	208981_at	3928	cg03886110	−0.50	−1.49	1.19E-10	0.20	0.72	0.52	1.07	2.39E-11

^aProbes used for the gene expression profiling.
^bProbes used for the methylation analysis.
^cCorrelation between gene expression and methylation status.
^dDifferential median values of gene in tumor/normal tissue samples (log₂ ratio).
^eStatistical significance of gene expression by paired t test.
^fDifferential median values of methylated probes versus unmethylated probes (M value).
^gStatistical significance of methylation examined by paired-t test.

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Table 1 Genes with negative correlation between gene expression and methylation.

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