Table 3 Poor prognostic factors of HCC after curative therapy.

Variable	Case No.	Univariate analysis		Multivariate analysis
Variable	Case No.	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p
Age >65/≤65 years	215/171	1.297(0.909–1.850)	0.151
Sex male/female	280/106	1.116(0.752–1.658)	0.585
HBsAg positive/negative	207/179	0.905(0.641–1.277)	0.569
Anti-HCV positive/negative	134/252	0.979(0.683–1.403)	0.908
Albumin ≤4/>4 g/dL	258/126	1.698(1.134–2.544)	0.010
Bilirubin >1.6/≤1.6 mg/dL	50/336	1.755(1.126–2.735)	0.013
ALT > 40/≤40 U/L	210/176	1.249(0.881–1.771)	0.211
AST > 45/≤45 U/L	210/175	1.740(1.218–2.485)	0.002
Platelet ≤10⁵/>10⁵/mm³	125/261	1.990(1.403–2.823)	<0.001	1.909(1.303–2.797)	0.001
PT INR > 1.1/≤1.1	159/227	1.437(1.012–2.041)	0.043
Ascites (yes/no)	63/323	1.938(1.305–2.877)	0.001
AFP > 20/≤20 ng/ml	209/177	2.096(1.456–3.016)	<0.001	1.674(1.144–2.450)	0.008
Multiple tumor (yes/no)	94/292	1.398(0.960–2.034)	0.080
Tumor size >3/≤3 cm	166/220	1.532(1.086–2.161)	0.015	1.844(1.249–2.723)	0.002
Vascular invasion (yes/no)	21/365	3.659(2.009–6.665)	<0.001	3.312(1.797–6.103)	<0.001
EGV (yes/no)	143/243	1.597(1.129–2.257)	0.008	1.629(1.117–2.376)	0.011

Abbreviations: CI: confidence interval; HBsAg: hepatitis B surface antigen; HCV: hepatitis C virus; MELD: model for end-stage liver disease; ALT: alanine aminotransferase; AST: aspartate aminotransferase; Alk-P: alkaline phosphate; PT INR: prothrombin time international normalized ratio; AFP: alpha-fetoprotein; EGV: esophagogastric varices.

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