Figure 3: CBR2 antagonism during immunization upregulates specific Immunomodulatory genes and genes associated with endocannabinoid signaling in activated inguinal lymph nodes. | Scientific Reports

Figure 3: CBR2 antagonism during immunization upregulates specific Immunomodulatory genes and genes associated with endocannabinoid signaling in activated inguinal lymph nodes.

From: Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice

Figure 3

Lymph nodes from Immunized 8 week old mice treated with 10 mg/kg AM630 or Vehicle from days 0–4 post-immunization were harvested at day 5 and analyzed by qPCR. Bar graphs derived from relative gene expression levels normalized to GAPDH and expressed as mean fold change over day 0 values ± SEM (n = 4), ∗P < 0.05, compared with vehicle, Statistical differences were determined by nonparametric Mann-Whitney U test.

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