Figure 3: The graphs indicate a significant positive correlation between the percentage of DNA methylation in CpG 1 in intron 7 of the FKBP5 gene and cortical thickness.
Panel A indicates the positive correlation between methylation status and cortical thickness of the right transverse frontopolar gyrus in C homozygote individuals (r = 0.353, Pcorr = 0.040). Panel B represents the post-hoc analysis of the correlations in each diagnostic group within the C homozygote group (C homozygous MDD patient group: r = 0.293, Pcorr > 0.05; C homozygous HC group: r = 0.371, Pcorr > 0.05). Trend lines (green, C homozygote group; blue, C homozygous MDD patient group; red, C homozygous HC group) obtained from bivariate linear regression analyses are presented in the graphs. The Correlation analysis was performed using a two-tailed Pearson’s partial correlation adjusted for age, gender, education level, medication, diagnosis, and total intracranial cavity volume. No significant correlations were observed in the other brain regions or subgroups. (MDD, major depressive disorder; HC, healthy control; CC, C allele homozygous individuals; MDD-CC. C allele homozygous patients with MDD; HC-CC, C allele homozygous healthy controls).
