Table 2 Summary of differences in volume and thickness of various brain regions among groups determined by genotype and diagnosis.

Brain regions	MDD (n = 114) vs. HC (n = 88)			CC (n = 130) vs. CT + TT (n = 72)				Diagnosis × Genotype interaction
Brain regions	F	P_uncorr	P_corr	F	P_uncorr	P_corr		F	P_uncorr	P_corr
*cortical volume*
L pars triangularis	1.387	>0.1	>0.1	1.223	>0.1	>0.1		11.074	0.001 ^*	0.027 ^*
L supramarginal gyrus	0.059			2.391				11.832	0.001 ^*	0.027 ^*
L superior parietal lobule	0.896			2.704				14.179	<0.001 ^*	0.017 ^*
R posterior mid-cingulate gyrus	0.089			0.027				9.158	0.003 ^*	0.043 ^*
R frontomarginal gyrus	1.337			0.935				9.508	0.002 ^*	0.043 ^*
R subcentral gyrus	0.367			19.996	<0.001 ^*	0.001 ^*	CC > CT + TT	1.395	0.239	>0.1

The F and uncorrected P values were obtained using analysis of covariance (ANCOVA) adjusted for age, gender, education level, medication, and total intracranial volume as covariates. Only brain regions with significant difference or interaction after the multiple comparison correction are shown. The False Discovery Rate (FDR) was applied in each analysis for multiple comparison correction, q < 0.05; cortical volume: 76 comparisons in both hemispheres; cortical thickness: 76 comparisons in both hemispheres; subcortical volume: 14 comparisons in both hemispheres. ^*Regions that remained significant after the multiple comparison correction are marked with an asterisk. MDD, major depressive disorder; HC, healthy controls; CC, CC genotype of rs1360780; CT + TT, CT or TT genotype of rs1360780; L, left hemisphere; R, right hemisphere; P_uncorr, uncorrected P-value; P_corr, FDR-corrected P-value.

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