Table 3 Summary of correlation analyses among gray-matter volumes or cortical thickness and DNA methylation in intron 7 of the FKBP5 gene among groups determined by diagnosis and genotype.

From: Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder

Subgroups

Brain regions

r

Puncorr

Pcorr

CpG

cortical thickness

CC (n = 118)

R transverse frontopolar gyrus

0.353

<0.001

0.040

pos 1

  1. A two-tailed Pearson’s partial correlation was performed to analyze the correlations of FKBP5 gene DNA methylation with cortical gray-matter volumes or thickness adjusting for age, gender, education level, medication, total intracranial cavity volume, FKBP5 genotype (only included in the analyses of MDD or HC groups), and diagnosis (only included in the analyses of T allele carrier or C homozygote groups). A hierarchical moderated regression analysis was performed to investigated the interactive effect of the DNA methylation with the diagnosis, genotype, or both diagnosis and genotype in terms of the correlation with the cortical gray-matter volumes or thickness. Only regions with significant correlations after multiple comparison correction are shown. The False Discovery Rate (FDR) was applied in each analysis for multiple comparison correction, q < 0.05; for cortical gray-matter volumes or thickness in the analysis of diagnostic effect (MDD or HC group): 304 comparisons (=38 cortical regions × 2 hemispheres × 2 diagnostic groups × 2 CpG sites); genotype effect (T allele carrier or C homozygote group): 304 comparisons (=38 cortical regions × 2 hemispheres × 2 genotype groups × 2 CpG sites); and interactive effects: 456 comparisons (=38 cortical regions × 2 hemispheres × 3 interactions × 2 CpG sites); for subcortical volumes in the analysis of diagnostic effect: 56 comparisons (=7 subcortical regions × 2 hemispheres × 2 diagnostic groups × 2 CpG sites); genotype effect: 56 comparisons (=7 subcortical regions × 2 hemispheres × 2 genotype groups × 2 CpG sites); and interactive effects: 84 comparisons (=7 subcortical regions × 2 hemispheres × 3 interactions × 2 CpG sites). MDD, major depressive disorder; HC, healthy control; CC, participants with CC genotype of rs1360780; R, right hemisphere; Puncorr, uncorrected P value; Pcorr, FDR-corrected P-value.
Back to article page