Figure 4: ROC curves for Acute Megakaryoblastic Leukemia (AMKL).
From: FocusHeuristics – expression-data-driven network optimization and disease gene prediction
To exemplify the concept of ROC curves, for AMKL and its corresponding gene expression data set, the ROC curves for each method are shown. The x-axis represents the specificity-related false positive rate (FPR), the y-axis sensitivity by the fraction of reference genes predicted (TPR, true positive rate). Methods are delineated by colour. The genes from the reduced reference data set (pleiotropic genes associated with 10 diseases or more have been removed, see Results section) were used. In the online supplement (http://focusheuristics.expressence.de/) respective figures are given for all 111 investigated data sets.
