Table 1 Baseline Demographic and Clinical Characteristics of the Study Population.
Increase (eGFR Change >20%) | Stable (eGFR Change −20 to 20%) | Severe Decline (eGFR Change >−20%) | P Value | |
|---|---|---|---|---|
N (%) | 2,477 (7.36) | 29,386 (87.32) | 1,791 (5.32) | |
Age, mean (SD), y | 74.87 (5.60) | 75.41 (5.38) | 75.86 (5.63) | <0.0001 |
Age group, y | <0.0001 | |||
65–74 | 1,244 (50.22) | 13,716 (46.68) | 752 (41.99) | |
75–84 | 1,103 (44.53) | 13,941 (47.44) | 902 (50.36) | |
≥85 | 130 (5.25) | 1,729 (5.88) | 137 (7.65) | |
Male | 1,241 (50.10) | 16,935 (57.63) | 1,058 (59.07) | <0.001 |
Education level, y | 0.194 | |||
<7 | 783 (31.61) | 8,672 (29.51) | 527 (29.42) | |
7–12 | 858 (34.64) | 10,672 (36.32) | 666 (37.19) | |
>12 | 836 (33.75) | 10,042 (34.17) | 598 (33.39) | |
Current smoker, n (%) | 164 (6.62) | 2,098 (7.14) | 125 (6.98) | 0.616 |
Alcohol, n (%) | 30 (1.21) | 490 (1.67) | 19 (1.06) | 0.038 |
Comorbidities, n (%) | ||||
Coronary artery disease | 320 (12.92) | 3853 (13.11) | 242 (13.51) | 0.847 |
Hypertension | 1,172 (47.32) | 14,015 (47.69) | 913 (50.98) | 0.023 |
Diabetes mellitus | 199 (8.03) | 2,579 (8.78) | 177 (9.88) | 0.109 |
Hyperlipidemia | 1,055 (42.59) | 13,550 (46.11) | 965 (53.88) | <0.0001 |
Laboratory measurement; mean (SD) | ||||
Serum albumin, g/dL | 4.33 (0.30) | 4.37 (0.29) | 4.39 (0.33) | <0.0001 |
Glucose, mg/dL | 101.30 (20.63) | 104.14 (23.77) | 108.14 (27.84) | <0.0001 |
Cholesterol, mg/dL | 195.67 (33.84) | 196.14 (34.16) | 198.04 (35.74) | 0.056 |
Triglyceride, mg/dL | 125.26 (73.39) | 121.33 (69.90) | 134.02 (84.02) | <0.0001 |
Uric acid, mg/dL | 5.80 (1.35) | 6.00 (1.46) | 6.52 (1.74) | <0.0001 |
White blood cell count, 103/μL | 5.70 (1.38) | 5.81 (1.40) | 6.04 (1.50) | <0.0001 |
Hemoglobin, g/dL | 13.7 (1.71) | 13.8 (2.51) | 13.5 (1.62) | <0.0001 |
High-density lipoprotein (HDL), g/dL | 52 (13.49) | 53 (13.69) | 50 (13.71) | <0.0001 |
Baseline eGFR, ml/min; n (%) | <0.0001 | |||
>90 | 65 (2.62) | 1,938 (6.59) | 115 (6.42) | |
89–60 | 1,342 (54.18) | 17,378 (59.14) | 930 (51.93) | |
45–59 | 877 (35.41) | 8,328 (28.34) | 538 (30.04) | |
30–44 | 162 (6.54) | 1,577 (5.37) | 156 (8.71) | |
<30 | 31 (1.25) | 165 (0.56) | 52 (2.90) | |
Proteinuria, n (%) | <0.0001 | |||
Negative | 2,131 (86.46) | 24,760 (84.55) | 1,413 (79.20) | |
+/‒ | 141 (5.73) | 2264 (7.75) | 125 (7.03) | |
+ | 112 (4.55) | 1,387 (4.75) | 141 (7.93) | |
++ and more | 80 (3.25) | 861 (2.95) | 104 (5.85) |
