Table 2 Incidence Rates of Cognitive Deterioration And Cognitive Deterioration or Death In the Study Populationa.
Percentage Change in eGFR | Cognitive Deterioration Follow-up Time (years) [median (Q1-Q3)] | Study Outcome, HR (95%CI) | |||||||
|---|---|---|---|---|---|---|---|---|---|
No. of Events | Incidence Rate (per 1,000 Person-years) | Cognitive Deterioration | Cognitive Deterioration or Death | ||||||
Cognitive Deterioration | Cognitive Deterioration or Death | Cognitive Deterioration | Cognitive Deterioration or Death | Unadjusted | Adjusted | Unadjusted | Adjusted | ||
All | 5.4 (5.2–5.6) | 924 | 2,832 | 5.5 | 17.0 | ||||
Increase (> +20%) | 5.5 (5.3–5.6) | 84 | 236 | 6.5 | 18.3 | 1.23 (0.98–1.54) | 1.09 (0.85–1.39) | 1.09 (0.95–1.25) | 1.09 (0.94–1.25) |
Stable (+20% to −20%) | 5.4 (4.5–5.6) | 763 | 2,362 | 5.3 | 16.4 | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
Severe decline (> −20%) | 5.5 (5.3–5.6) | 77 | 234 | 8.2 | 25.1 | 1.54 (1.21–1.94) | 1.33 (1.08–1.72) | 1.49 (1.30–1.70) | 1.17 (1.03–1.35) |
Non CKD Baseline eGFR ≥60 | |||||||||
Increase (> +20%) | 5.5 (5.3–5.6) | 68 | 180 | 6.0 | 15.9 | 1.29 (1.01–1.67) | 1.14 (0.56–1.51) | 1.19 (1.02–1.39) | 1.14 (0.96–1.35) |
Stable (+ 20% to −20%) | 5.4 (4.6–5.6) | 249 | 1,318 | 4.6 | 13.0 | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
Severe decline (> −20%) | 5.6 (5.4–5.7) | 14 | 36 | 4.5 | 11.5 | 0.94 (0.55–1.60) | 1.28 (0.75–2.17) | 0.85 (0.61–1.18) | 1.05 (0.75–1.47) |
CKD Baseline eGFR < 60 | 373 | 1,298 | |||||||
Increase (> + 20%) | 5.5 (5.3–5.6) | 16 | 56 | 10.2 | 35.8 | 1.49 (0.90–2.47) | 1.09 (0.62–1.91) | 1.44 (1.10–1.89) | 1.15 (0.86–1.53) |
Stable (+ 20% to −20%) | 5.4 (4.4–5.6) | 294 | 1,044 | 6.9 | 24.4 | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
Severe decline (> −20%) | 5.5 (5.3–5.6) | 63 | 198 | 10.2 | 31.9 | 1.47 (1.12–1.94) | 1.36 (1.03–1.83) | 1.27 (1.09–1.48) | 1.14 (0.96–1.34) |
