Table 3 LysoPC a C20:3 varied with Child-Pugh Class in patients with HBV-associated cirrhosis and HBV-associated HCC.

From: Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients

Variables

HBV-associated cirrhosis

HBV-associated HCC

Class A

Class B

Class C

Class A

Class B

Class C

N

17

82

5

20

65

10

Age(ys)

58.00(54.00–61.00)

56.50(48.25–62.75)

53.00(36.00–66.00)

57.00(49.75–63.25)

57.00(47.00–61.00)

51.50(43.25–57.50)

BMI(kg/m2)

23.83(22.10–26.03)

23.25(20.62–25.06)

23.78(22.85–25.21)

23.48(21.71–24.80)

22.20(19.38–23.67)

21.46(19.74–24.57)

Gender(F/M)

8/9

33/49

2/3

4/16

9/56

1/9

lysoPC a C18:0 (μmol/L)

23.67(18.87–28.45)

26.31(18.29–35.55)

18.89(6.55–19.50)

25.87(17.09–30.83)

22.77(15.46–31.37)

17.05(10.67–19.84)

lysoPC a C18:2 (μmol/L)Δ

22.10(18.75–23.17)

18.76(13.11–26.55)

9.00(8.49–13.00)

17.98(13.07–25.70)

15.19(10.44–20.73)

12.86(7.96–16.66)

lysoPC a C20:3 (μmol/L)Δ

1.31(1.01–1.66)

1.19(0.83–1.55)

0.89(0.44–0.94)*#

1.25(0.92–1.64)

0.97(0.78–1.47)

0.68(0.54–0.89)**##

lysoPC a C20:4 (μmol/L)Δ

3.52(2.53–4.05)

3.70(2.70–5.05)

2.17(2.03–2.57)*###

3.42(2.53–4.37)

3.21(2.45–4.34)

2.11(1.86–3.06)

lysoPC a C24:0 (μmol/L)

0.33(0.19–0.50)

0.31(0.20–0.45)

0.27(0.21–0.29)

0.35(0.24–0.40)

0.27(0.16–0.42)

0.24(0.10–0.37)

PC ae C42:1 (μmol/L)

0.27(0.21–0.33)

0.30(0.22–0.37)

0.19(0.18–0.28)

0.26(0.20–0.30)

0.27(0.22–0.33)

0.24(0.15–0.29)

AC C18:2 (μmol/L)Δ

0.11(0.05–0.14)

0.14(0.09–0.20)

0.16(0.12–0.19)

0.08(0.05–0.11)

0.11(0.08–0.16)*

0.12(0.06–0.15)

AC C3-OH (μmol/L)

0.14(0.13–0.18)

0.15(0.12–0.20)

0.12(0.10–0.13)#

0.18(0.12–0.23)

0.16(0.12–0.21)

0.16(0.13–0.24)

SM C24:1 (μmol/L)

20.67(15.25–33.84)

21.58(12.16–31.81)

26.94(25.69–36.83)

20.83(14.77–27.00)

32.86(16.48–50.64)*

42.22(30.45–64.50)*

  1. Values are expressed as medians (25th, 75th centiles) or frequencies. P values were calculated from non-parametric Kruskal-Wallis test for continuous variables, Fisher’s exact test for categorical variables for multiple comparisons correction and adjusted by FDR method. *p < 0.05; **p < 0.01; ***p < 0.001 when compared to Class A. #p < 0.05; ##p < 0.01; ###p < 0.01when compared to Class B. ΔThe metabolites are still independent variables for disease classification considering the effect of age, gender and BMI based on multiple logistic regression.
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