Table 4 LysoPC a C20:4 varied with MELD Score and disease progression from CHB to HBV-associated cirrhosis and to HBV-associated HCC.

From: Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients

Variables

CHB

HBV-associated cirrhosis

HBV-associated HCC

MELD≤8.99

MELD>8.99

MELD≤8.99

MELD>8.99

MELD≤8.99

MELD>8.99

N

109

27

29

75

30

65

Age(ys)

40.00(32.00–51.00)

45.00(35.50–58.00)

55.00(50.00–62.00)

57.00(48.50–64.50)

56.00(47.00–64.50)

56.00(47.00–61.00)

BMI(kg/m2)

23.66(22.03–24.91)

23.67(21.76–24.28)

23.51(20.58–25.71)

23.44(21.16–25.14)

22.07(19.36–23.71)

22.32(19.82–24.22)

Gender(F/M)

45/64

6/21

15/14

28/47

7/23

7/58

lysoPC a C18:0(μmol/L)

35.83(24.65–44.59)

30.38(26.94–40.27)

32.1(21.47–43.82)

22.97(16.04–33.77)*

30.66(25.39–36.05)

17.76(14.31–25.86)***

lysoPC a C18:2(μmol/L)Δ

24.06(19.85–29.05)

20.47(14.09–28.31)

22.46(17.47–29.85)

18.22(12.49–24.97)

20.31(16.81–26.36)

13.25(9.87–19.22)**

lysoPC a C20:3(μmol/L)Δ

1.51(1.21–1.94)

1.46(1.07–1.94)

1.42(1.09–1.80)

1.10(0.80–1.52)*

1.46(0.98–1.68)

0.89(0.72–1.20)***

lysoPC a C20:4(μmol/L)Δ

4.91(3.61–6.25)

3.92(3.22–5.68)*

4.73(3.32–5.88)

3.17(2.34–4.37)**

3.86(2.76–5.37)

2.78(2.02–3.76)**

lysoPC a C24:0(μmol/L)

0.43(0.26–0.55)

0.35(0.25–0.69)

0.39(0.16–0.54)

0.29(0.20–0.41)

0.24(0.15–0.42)

0.29(0.19–0.41)

PC ae C42:1(μmol/L)

0.34(0.28–0.40)

0.29(0.27–0.35)*

0.30(0.22–0.38)

0.29(0.20–0.36)

0.26(0.21–0.30)

0.26(0.20–0.33)

AC C18:2(μmol/L)Δ

0.09(0.04–0.13)

0.10(0.07–0.13)

0.13(0.06–0.15)

0.15(0.09-0.20)

0.09(0.07–0.15)

0.11(0.07–0.16)

AC C3-OH(μmol/L)

0.18(0.14–0.22)

0.18(0.14–0.21)

0.18(0.12–0.22)

0.14(0.12–0.18)

0.17(0.14–0.22)

0.16(0.12–0.22)

SM C24:1(μmol/L)

27.16(17.74–38.11)

35.38(23.43–46.77)

21.49(8.14–35.62)

21.67(15.15–31.74)

22.84(14.18–39.60)

32.86(18.55–48.79)

  1. Values are expressed as medians (25th, 75th centiles) or frequencies. P values were calculated from non-parametric Kruskal-Wallis test for continuous variables, Fisher’s exact test for categorical variables for multiple comparisons correction and adjusted by the FDR method. *p < 0.05; **p < 0.01; ***p < 0.001 when compared to MELD ≤ 8.99. ΔThe metabolites are still independent variables for disease classification considering the effect of age, gender and BMI based on multiple logistic regression.
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