Figure 2: Extracellular histones induced thrombocytopenia.

Mice were injected with histone or saline (45 μg/g, n = 6 per group). The blood samples were collected at 1–12 h after injection. The numbers of white blood cells (WBCs), red blood cells (RBCs), and platelets are shown in figure (A–C), respectively. Data are presented as percentage of the vehicle group. The figures show the experimental means ± SD. *P < 0.05, **P < 0.01 vs Histone group of C5-deficient (Scheffe’s test).