Figure 3: Extracellular histones prolonged plasma activated partial thromboplastin time (APTT) and prothrombin time (PT) in C5-sufficient mice.

Mice were injected with histone or saline (45 μg/g, n = 6 per group). The blood samples were collected at 1–6 h after injection. APTT at 1, 3 and 6 h are shown in figure (A–C), respectively. PT at 1, 3 and 6 h are also shown in (D–F), respectively. *P < 0.05 vs Vehicle group of C5 sufficient (Scheffe’s test).