Figure 4: Extracellular histones induced severe liver dysfunction. | Scientific Reports

Figure 4: Extracellular histones induced severe liver dysfunction.

From: Complement component 5 promotes lethal thrombosis

Figure 4

Mice were injected with histone or saline (45 μg/g, n = 6 per group). Histological findings are show in fig. (A to D) at 6 h after histone injection. (A) Vehicle group of C5-sufficient, (B) Histone group of C5-sufficient, (C) Vehicle group of C5-deficient, (D) Histone group of C5-deficient. H&E stain. Scale bar, 100 μm. Black allows indicates embolism. The blood samples were collected at 1–6 h after histone injection. Liver function were defined as AST, ALT and LDH levels, and these are shown in (E–G), respectively. The figures show the experimental means ± SD. *P < 0.05, **P < 0.01 vs Histone group of C5-deficient (Scheffe’s test).

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