Figure 9: Summary for the mechanism of liver injury induced by histone. | Scientific Reports

Figure 9: Summary for the mechanism of liver injury induced by histone.

From: Complement component 5 promotes lethal thrombosis

Figure 9

The black dotted arrow show previously known interactions of these systems. The black solid arrows identify the new paths in the present study. Histones induce platelet aggregation and coagulation disorder; the coagulation disorder promotes cleavage of C5. C5a increases the expression of CD11b (CR3). CR3 binds to CD41 (GPIIb), and this aggregations induce embolism. Embolism accelerates liver injury.

Back to article page