Figure 3: Identification of TRPM7 transphosphorylation sites by TRPM6. | Scientific Reports

Figure 3: Identification of TRPM7 transphosphorylation sites by TRPM6.

From: Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases

Figure 3

The diagram on the left depicts the amino acid sequence of mouse TRPM7 (UniProtKB: Q923J1). The cytosolic N-terminus, the coiled-coil domain, the S/T-rich domain, the exchange segment, and the alpha-kinase domain are colored in blue, orange, green, yellow and red respectively. Phosphorylated residues introduced by TRPM6 on TRPM7 are displayed by red circles and residues identified in the control kinase-inactive TRPM7 are displayed as blue circles. The chart on the right summarizes all identified phosphorylation residues from the analysis. Bold italic represents residues on TRPM7 that are both autophosphorylated and transphosphorylated by TRPM6.

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