Figure 5: IFN-γ production in response to B. pseudomallei is reduced in individuals with DM.
From: Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei
Whole blood of healthy seropositive individuals (n = 75) and individuals with DM (n = 11) were incubated with killed B. pseudomallei (30:1 ratio), 10 μg/ml of E. coli LPS or medium alone and culture supernatants assayed for IFN-γ (a) and IL-10 (b) by ELISA after 48 hours in vitro. The data are presented with the mean and the standard deviation. Statistical significance was determined by Mann-Whitney test; ns, non significant, *p < 0.05, **p < 0.01 and ***p < 0.001.
