Figure 5: PEDF dampened neovascularization by mediating macrophage polarization in OIR mice. | Scientific Reports

Figure 5: PEDF dampened neovascularization by mediating macrophage polarization in OIR mice.

From: PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy

Figure 5

(a) Quantification of M1-like macrophages related MCP-1, iNOS, IL-1β and M2-like macrophages related CD206, CD163, Arg-1 mRNA expression in the retinal of normal and OIR mice at postnatal day 15, 17 and 21 treated with or without PEDF. (b) Western blot analysis of iNOS and Arg-1 expression in the retinal of normal and OIR mice at postnatal day 15, 17 and 21 treated with PEDF or not. *P < 0.05, **P < 0.01, ***P < 0.001. P values were analyzed by one-way ANOVA. All data are representative of three independent experiments with n = 5 per group and are means ± SEM.

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