Figure 2: Differentially expressed genes in SSc skin tissues.
From: Integration of microRNA and mRNA expression profiles in the skin of systemic sclerosis patients
(A) Microarray data for 31 SSc and 9 normal control samples were obtained from the NCBI GEO Database (GSE9285). (B) In all, 2698 genes were dysregulated in SSc skin tissues (1133 were upregulated, and 1565 were downregulated). (C) Networks representing the TLR, TGF-β and Wnt pathways were manually curated by combining KEGG pathway information with data for the miRNAs and their predicted targets. Nodes represent dysregulated miRNAs (circle) and genes (square) in the pathways. Node colours (red for upregulation and green for downregulation) represent fold changes in the corresponding miRNAs or genes.
