Figure 6: BoNT/C1 ad does not impair spontaneous pre-synaptic neurotransmitter release.
From: Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery
(A) Representative whole-cell voltage-clamp recordings; (B) normalized mEPSC frequencies; (C) cell membrane capacitances, and (D) resting membrane potentials from mESN cultures treated with vehicle, wt BoNT/C1 (400 fM, equivalent to 2 mouse LD50 units/mL), or BoNT/C1 ad (100 nM, equivalent to 0.2 mouse LD50 units/mL) for 20 h. Normalized data are from 12–16 recordings per treatment, and are presented as mean ± SEM; ***p < 0.001.
