Figure 5: Model of FCMR binding to human IgM.
From: Glycan-independent binding and internalization of human IgM to FCMR, its cognate cellular receptor
(a) Homology model of the monomeric Ig-like domain of hFCMR (left panel). The CDR regions expected to directly contact IgM are shown in stick representation (yellow). Final model of the interaction between the Fc domain of hIgM and hFCMR (right panel). (b) Finer details of the IgM/FCMR interface. The residues of one protein that are within 3 Å of the other protein for more than 75% of the simulations are shown in stick representation. The upper panel shows the hydrophobic residues within this interface, and the lower panel shows the polar residues. The hydrophobic, positively charged, negatively charged, and polar residues are colored white, blue, red, and orange respectively.
