Figure 6: IgM inhibits T cell proliferation.
From: Glycan-independent binding and internalization of human IgM to FCMR, its cognate cellular receptor
Various concentrations of IgM or BSA were incubated with 5 μg/ml PHA for 30 min at 4 °C, prior to five day incubation with CellTrace Violet-labeled PBMCs at 37 °C. PHA alone was used as a positive control and media only as a negative control (grey trace, lower panels). Percentage of proliferating CD4+ and CD8+ T cells (panels A and B, respectively) were normalized to samples incubated with PHA and BSA (upper panels). Data are represented as mean ± SD of two independent experiments.
