Figure 8: Model of anti-DENV cell response by RESV treatment. | Scientific Reports

Figure 8: Model of anti-DENV cell response by RESV treatment.

From: Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection

Figure 8

DENV infection triggers the acetylation of HMGB1 in the nucleus, causing the release of HMGB1 into the cytoplasm and extracellular milieu. RESV treatment induces production of Sirt1, leading to deacetylation of HMGB1. This then reduces the translocation of HMGB1 and increases the accumulation of HMGB1 in the nucleus. The higher amount of nuclear HMGB1 enhances the production of ISGs, leading to efficient antiviral response in the cell.

Back to article page