Table 4 Effect of exposure to environmental factors on DUSP1 methylation in tumour DNA.

From: DUSP1 promoter methylation in peripheral blood leukocyte is associated with triple-negative breast cancer risk

Environmental factors (%)

DUSP1 methylation

ORcrude (95% CI)

P-value

ORadj (95% CI)

P-value

Methylated

Un-methylated

Fruit (g/week)

   

0.021

 

0.023

 ≤1000

89 (67.9)

42 (32.1)

1.000

 

1.000

 

 >1000

100 (54.9)

82 (45.1)

0.576 (0.360–0.920)

 

0.567 (0.348–0.924)

 

Soybean (times/week)

   

0.007

 

0.006

 ≤1

72 (51.8)

67 (48.2)

1.000

 

1.000

 

 >1

119 (66.9)

59 (33.1)

1.877 (1.189–2.962)

 

1.955 (1.211–3.154)

 

Menstrual regularity

   

0.014

 

0.020

 regular

134 (55.8)

106 (44.2)

1.000

 

1.000

 

 irregular

54 (72.0)

21 (28.0)

2.034 (1.156–3.578)

 

2.000 (1.113–3.593)

 
  1. ORcrude, odds ratio generated by univariate logistic regression; ORadj, odds ratio generated by multivariate logistic regression; 95%CI, 95% confidence interval.
Back to article page