Table 5 Association of environmental exposures and DUSP1 methylation in tumour DNA by ER and PR status.

From: DUSP1 promoter methylation in peripheral blood leukocyte is associated with triple-negative breast cancer risk

Environmental factors (%)

ER−

ER+

PR−

PR+

Metha

Unmethb

ORadjc (95%CI) P-value

Metha

Unmethb

ORadjc (95%CI) P-value

Metha

Unmethb

ORadjc (95%CI) P-value

Metha

Unmethb

ORadjc (95%CI) P-value

Soybean (times/week)

 ≤1

29

19

1.000

43

47

1.000

36

27

1.000

36

39

1.000

 >1

50

11

2.978 (1.245–7.124) 0.017

68

48

1.548 (0.889–2.696) 0.159

62

17

2.735 (1.315–5.692) 0.010

56

42

1.444 (0.789–2.643) 0.282

Menstrual regularity

 Yes

58

21

1.000

75

84

1.000

69

31

1.000

64

74

1.000

 No

19

10

0.688 (0.276–1.716) 0.475

35

11

3.564 (1.691–7.511) 0.001

27

13

0.933 (0.425–2.047) 0.863

27

8

3.902 (1.656–9.194) 0.001

  1. aMeth, methylated; bUnmeth, unmethylated; cORadj, odds ratio generated by multivariate logistic regression; 95%CI, 95% confidence interval.