Figure 1: Planar cell polarity (PCP) in the mouse vestibule. | Scientific Reports

Figure 1: Planar cell polarity (PCP) in the mouse vestibule.

From: Establishment of planar cell polarity is coupled to regional cell cycle exit and cell differentiation in the mouse utricle

Figure 1

(A) An overview of the mouse vestibular system. (B) PCP of the saccule (SA). The line of polarity reversal (LPR, white line) is located within the striola, marked by the OCM+ (blue) type I hair cells. Hair cells are oriented with their fonticulus visible and stereociliary bundles pointed away from the LPR. (C) PCP of the utricle (UT), anterior cristae (AC), and lateral cristae (LC). In the utricle, the LPR is located lateral to the striola. Hair cells are oriented with their fonticulus visible and stereociliary bundles pointed toward the LPR. Hair cells in the lateral cristae are oriented in a manner similar to the hair cells lateral of the LPR in the utricle. Hair cells in the anterior cristae are oriented in a manner similar to hair cells medial of the LPR in the utricle. (D) PCP of the posterior cristae (PC). The hair cells are oriented posteriorly in the same direction as those medial to the LRP in the utricle. The boxed regions in (B–D) were all presented at a higher magnification. Atoh1/EGFP (green) marks all hair cells; β-spectrin (red) labels the actin-rich cuticular plate; OCM (blue) is expressed in type I hair cells in the striola. Scale bar: 50 μm.

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