Table 3 Parameter estimates of two compartment pharmacokinetic model for Alteplase and mt-PA.

Parameter		s.e.	r.s.e.(%)	β_{cov (Alteplase,mt-PA dose)}		p-value^*	β_{cov (Alteplase,mt-PA)}		p-value^*
α (Dose = 4000*)	0.383	0.03	8
α (Dose = 100)	0.32	0.064	20	β_{(α,Dose=100)}	−0.18	0.4
α (Dose = 200)	0.527	0.19	36	β_{(α,Dose=200)}	0.32	0.39
α (Dose = 400)	0.358	0.044	12	β_{(α,Dose=400)}	−0.0658	0.65	β_{(α,Dose=mt-PA)}	−0.0362	0.79
β (Dose = 4000*)	0.0811	0.0074	9
β (Dose = 100)	0.0331	0.0029	9	β_{(β,Dose=100)}	−0.897	<1E-010
β (Dose = 200)	0.0367	0.0025	7	β_{(β,Dose=200)}	−0.794	<1E-010
β (Dose = 400)	0.0254	0.0015	6	β_{(β,Dose=400)}	−1.16	<1E-010	β_{(β,Dose=mt-PA)}	−0.981	<1E-010
A (Dose = 4000*)	0.00176	0.00015	9
A (Dose = 100)	0.0144	0.0028	19	β_(A,Dose=100)	2.1	<1E-010
A (Dose = 200)	0.0148	0.0061	41	β_(A,Dose=200)	2.13	4.4E−07
A (Dose = 400)	0.0124	0.0016	13	β_(A,Dose=400)	1.95	<1E-010	β_{(A,Dose=mt-PA)}	1.96	<1E-010
B (Dose = 4000*)	0.000191	4.E-05	21
B (Dose = 100)	0.00415	0.00089	21	β_(B,Dose=100)	3.08	<1E-010
B (Dose = 200)	0.00922	0.0016	17	β_(B,Dose=200)	3.88	<1E-010
B (Dose = 400)	0.00402	0.00058	14	β_(B,Dose=400)	3.05	<1E-010	β_{(B,Dose=mt-PA)}	3.31	<1E-010

Abbreviations: α, the distribution slope; β, the elimination slope; A, the y-intercept of the distribution phase; B, the y-intercept of the elimination phase. *P-values obtained from the Wald test only for the coefficients of the covariates.

Quick links

Search