Figure 5: Growth inhibition and DOX metabolite formation. | Scientific Reports

Figure 5: Growth inhibition and DOX metabolite formation.

From: Cationic Polymethacrylate-Modified Liposomes Significantly Enhanced Doxorubicin Delivery and Antitumor Activity

Figure 5

(a) Growth inhibition of a DOX resistant cell line (MCF-7/adr) by free DOX, DOX-LP and DOX-ERLP with a p value < 0.05. (b) HPLC analysis of cellular metabolites of DOX; tR 4.5 min (DOX), tR 11.2 min (DOX metabolites). (c) Time course of cellular DOX in DOX-ERLP treated samples. (d) Time course of the ratio between the metabolite (tR 11 min) and cellular DOX in MCF-7/adr cells treated with Free DOX (◽) and DOX-ERLP (▴). The ratio difference was significant with a p value < 0.01 (**).

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