Figure 1: Effects of PVN infusion of PD98059 on mean arterial pressure (MAP) in salt-induced hypertensive rats.

MAP in rats receiving high-salt diet increased gradually while PD98059 inhibited high salt diet-induced hypertension compared with the normal-salt (NS) diet rats (P < 0.05, n = 7). Values are mean ± SE. *P < 0.05 vs control (NS + PVN aCSF or NS + PVN PD98059); †P < 0.05, HS + PVN PD98059 vs HS + PVN aCSF.