Figure 3: Effects of PVN infusion of PD98059 on Fra-like (Fra-LI) positive neurons within the PVN in salt-induced hypertensive rats. | Scientific Reports

Figure 3: Effects of PVN infusion of PD98059 on Fra-like (Fra-LI) positive neurons within the PVN in salt-induced hypertensive rats.

From: PVN Blockade of p44/42 MAPK Pathway Attenuates Salt-induced Hypertension through Modulating Neurotransmitters and Attenuating Oxidative Stress

Figure 3

(A) A representative immunofluorescence image of Fra-LI immunoreactivity, an indicator of chronic neuronal excitation. (B) Densitometric analysis of Fra-LI positive neurons in PVN. PVN levels of Fra-LI immunoreactivity in High-salt diet (HS) rats were higher than in normal-salt (NS) rats (P < 0.05, n = 7). Chronic PVN infusions of PD98059 significantly reduced Fra-LI level in the PVN of HS rats compared with the NS rats (P < 0.05, n = 7). Values are mean ± SE. *P < 0.05 vs control (NS + PVN aCSF) or NS + PVN PD98059); †P < 0.05, HS + PVN PD98059 vs HS + PVN aCSF.

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