Figure 4: Effects of PVN infusion of PD98059 on PVN level of superoxide within the PVN in salt-induced hypertensive rats. | Scientific Reports

Figure 4: Effects of PVN infusion of PD98059 on PVN level of superoxide within the PVN in salt-induced hypertensive rats.

From: PVN Blockade of p44/42 MAPK Pathway Attenuates Salt-induced Hypertension through Modulating Neurotransmitters and Attenuating Oxidative Stress

Figure 4

(A) A representative immunofluorescence image of fluorescent-labeled dihydroethidium (DHE). (B) Densitometric analysis of DHE staining. (C) A representative immunoblot image of Cu/Zn-SOD. (D) Densitometric analysis of protein expression of Cu/Zn-SOD. High-salt diet (HS) rats showed stronger fluorescence intensity labeled with DHE and lower Cu/Zn-SOD proteins compared with normal-salt (NS) rats. PVN infusion PD98059 significantly decreased immunofluorescent intensity of DHE and increased Cu/Zn-SOD protein expression (P < 0.05, n = 7). Values are mean ± SE. *P < 0.05 vs control (NS + PVN aCSF or NS + PVN PD98059); †P < 0.05, HS + PVN PD98059 vs HS + PVN aCSF.

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