Figure 5: Effects of PVN infusion of PD98059 on PVN NOX2, a NAD (P) H oxidase subunit, in salt-induced hypertensive rats. | Scientific Reports

Figure 5: Effects of PVN infusion of PD98059 on PVN NOX2, a NAD (P) H oxidase subunit, in salt-induced hypertensive rats.

From: PVN Blockade of p44/42 MAPK Pathway Attenuates Salt-induced Hypertension through Modulating Neurotransmitters and Attenuating Oxidative Stress

Figure 5

(A) A representative immunofluorescence image of NOX2. (B) Densitometric analysis of NOX2. (C) A representative immunoblot image of NOX2. (D) Densitometric analysis of protein expression of NOX2. High-salt diet (HS) rats had higher levels of NOX2 compared with normal-salt (NS) rats (P < 0.05, n = 7). PVN infusion of PD98059 significantly attenuated NOX2 level within the PVN of HS rats (P < 0.05, n = 7). Values are mean ± SE. *P < 0.05 vs control (NS + PVN aCSF or NS + PVN PD98059); †P < 0.05, HS + PVN PD98059 vs HS + PVN aCSF.

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