Figure 7: Soluble fractalkine modulates cytokine release in rd10 explants and microglia.
From: Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina
(A,B) Relative levels of (A) chemokines and cytokines and (B) interleukins in P15 rd10 explants treated with 100 ng/ml soluble fractalkine compared to vehicle. Vehicle (0.1% BSA in 1x PBS) for each cytokine is represented by the dotted red line at 1 (N = 4 explants, n = 2 technical replicates). (C,D) Relative levels of (C) chemokines and cytokines and (D) interleukins in isolated rd10 microglia treated with soluble fractalkine compared to vehicle. Vehicle for each cytokine is represented by the dotted red line at 1 (N = 12 retinas, n = 2 technical replicates) (* highlights cytokines implicated in retinal degeneration).
