Table 1 Summary risk estimates of the association between selective serotonin reuptake inhibitor use and cardiovascular-related malformations.
No. of study | Summary RR (95%CI) | I2 (%) | P* | P** | |
|---|---|---|---|---|---|
Overall | 18 | 1.26 (1.13–1.39) | 53.6 | 0.003 | |
Cardiac malformation | 7 | 1.17 (1.06–1.28) | 31.0 | 0.19 | |
ASD | 6 | 2.06 (1.40–3.03) | 57.8 | 0.04 | |
VSD | 7 | 1.15 (0.97–1.36) | 30.3 | 0.20 | |
ASD and/or VSD | 14 | 1.27 (1.14–1.42) | 40.0 | 0.04 | |
Geographic Location | 0.52 | ||||
Northern America | 5 | 1.22 (1.12–1.34) | 0.0 | 0.51 | |
Europe | 11 | 1.27 (1.08–1.48) | 67.3 | 0.001 | |
Others | 2 | 1.71 (1.23–2.37) | 0.0 | 0.45 | |
Adjustment for confounders | |||||
Maternal age | 0.39 | ||||
Yes | 13 | 1.23 (1.07–1.41) | 62.7 | 0.001 | |
No | 5 | 1.34 (1.13–1.59) | 18.0 | 0.30 | |
Socioeconomic status | 0.23 | ||||
Yes | 4 | 1.39 (0.97–2.00) | 75.1 | 0.007 | |
No | 14 | 1.19 (1.09–1.30) | 29.5 | 0.14 | |
Smoking or alcohol drinking | 0.72 | ||||
Yes | 9 | 1.24 (1.05–1.47) | 72.7 | <0.001 | |
No | 9 | 1.27 (1.14–1.41) | 6.0 | 0.39 | |
Pregnancy BMI | 0.29 | ||||
Yes | 3 | 1.10 (0.89–1.36) | 0.0 | 0.70 | |
No | 15 | 1.29 (1.15–1.46) | 62.2 | 0.001 | |
Pregnancy complications | 0.06 | ||||
Yes | 6 | 1.13 (1.05–1.22) | 0.0 | 0.96 | |
No | 12 | 1.40 (1.17–1.67) | 63.1 | 0.002 | |
Parity | 0.73 | ||||
Yes | 6 | 1.31 (1.05–1.63) | 82.0 | <0.001 | |
No | 12 | 1.24 (1.14–1.34) | 0.0 | 0.47 | |
