Figure 8: Effects of PKCγ siRNA on AT1R and PKCγ expression in the PVN of salt-induced hypertensive rats. | Scientific Reports

Figure 8: Effects of PKCγ siRNA on AT1R and PKCγ expression in the PVN of salt-induced hypertensive rats.

From: Renin-angiotensin system acting on reactive oxygen species in paraventricular nucleus induces sympathetic activation via AT1R/PKCγ/Rac1 pathway in salt-induced hypertension

Figure 8

Expressions of AT1R and PKCγ in high salt intake (HS) rats were higher than in control rats. Microinjections of PKCγ siRNA attenuated the PKCγ expression and had no effect on the AT1R positive neurons in the PVN of HS rats. (A) Immunofluorescence for AT1R (bright green) and immunohistochemistry for PKCγ (bright brown) in the PVN in different groups. (B) and (C) Column diagram showing the numbers of AT1R and PKCγ positive neurous cells in the PVN in different groups. Values are expressed as means ± SE. *P < 0.05 vs NS groups (NS + PKCγ siRNA or NS + scrambled siRNA); †P < 0.05 HS + PKCγ siRNA vs HS + scrambled siRNA.

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